Post Image

Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study.


J Neuroimmunol. 2010 Oct 8; 227(1-2) : 185-9. Epub 2010 Aug 21.
Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study.
Yamout B, Hourani R, Salti H, Barada W, El-Hajj T, Al-Kutoubi A, Herlopian A, Baz EK, Mahfouz R, Khalil-Hamdan R, Kreidieh NM, El-Sabban M, Bazarbachi A.
Departments of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. yamoutba@idm.net.lb
Abstract
We explore the safety, and therapeutic benefit of intrathecal injection of ex-vivo expanded autologous bone marrow derived mesenchymal stem cells (BM-MSCs) in 10 patients with advanced multiple sclerosis (MS). Patients were assessed at 3, 6 and 12 months. Assessment at 3-6 months revealed Expanded Disability Scale Score (EDSS) improvement in 5/7, stabilization in 1/7, and worsening in 1/7 patients. MRI at 3 months revealed new or enlarging lesions in 5/7 and Gadolinium (Gd+) enhancing lesions in 3/7 patients. Vision and low contrast sensitivity testing at 3 months showed improvement in 5/6 and worsening in 1/6 patients. Early results show hints of clinical but not radiological efficacy and evidence of safety with no serious adverse events.
Copyright © 2010 Elsevier B.V. All rights reserved.
PMID: 20728948 [PubMed – indexed for MEDLINE]

Contact Us

Have questions about Stem Cell Therapy?
Fill out the form or contact us below and we’ll be in touch!

Join the Revolution

Learn how to take your practice to the next level. Set up a consultation below